In this two-day course, students will be introduced to using Claude Cowork, which is Anthropic's autonomous AI agent language and execution system used to manage complex, multi-step knowledge work directly within the Claude Desktop (https://claude.ai) environment. The course covers the structural requirements, permission frameworks, and interface dynamics needed to safely run computer use capabilities, but the emphasis is on leveraging Claude Cowork to handle long-running, autonomous business workflows. Students will learn how to configure persistent workspace context files, integrate native connectors and third-party Model Context Protocol (MCP) servers, build reusable custom AI skills, and schedule fully automated daily or weekly tasks. This instructor-led course consists of a combination of lecture, demonstrations, and hands-on labs.